When administered intravenously, the bioavailability is 100%. Amino acids are distributed in the interstitial fluid and extracellular space of tissues and organs. When testosterone propionate vs enanthate properly administered does not disturb the balance of amino acids. A small portion of the amino acid is eliminated by the kidneys.
Indications for use:
Partial or total parenteral nutrition in children under 5 years in conjunction with the carbohydrate solution, fat emulsion preparations and vitamins, electrolytes and trace elements (including when enteral nutrition is impossible or insufficient). If necessary, use an additional baby taurinsoderzhaschie drugs.
Contraindications for use:
Violation of amino acid metabolism, metabolic acidosis, hyperhydration, hypokalemia, shock, hypoxia, decompensated heart failure, hypersensitivity to the drug.
dosing regimen, the route of administration
Slowly injected intravenously (drip), preferably in the central vein at a rate of 2 ml / min (maximum of 40 drops per minute).
Allowed infusional drug together with a 5% glucose solution: the contents 2 – 3 ampoules testosterone propionate vs enanthate (according to the doctor’s prescription) was diluted in 200 ml of 5% glucose solution and administered at a rate of 25 – 35 drops per minute.
The maximum daily dose: Children aged 2 – amino 1.5-2.5 g per 1 kg of body weight, or from 25 ml to 40 ml S-2 per 1 kg of body weight per day; children over 2 years of age – 2.5 g of amino acids per 1 kg of body weight, or 25 ml per 1 kg of body weight per day.
In catabolic states – 1.3-2 g amino acids per kg / day.
The drug is administered as long as the need for parenteral nutrition.
Precautions for use
Use with caution in patients with renal / hepatic insufficiency.
In parenteral nutrition of young children the following parameters must be considered: urea nitrogen, ammonia, glucose, electrolytes, triglycerides (for additional administration of fat emulsions), the activity of “liver” enzymes, serum osmolarity, acid-base balance and water-salt metabolism.
Too rapid infusion could result in loss of amino acids through the kidneys, and thus, to the amino acid imbalance.
Amino acids contained in the product can become a breeding ground for microorganisms, and therefore the equipment for intravenous infusion should be thoroughly sterilized.
Overdose symptoms, relief measures in overdose
In excess doses may experience acute circulatory disorders. In this case, the introduction of the drug should be discontinued immediately.
Possible side effects when using the drug
When infusion of the drug signs of local reactions may be observed in the peripheral veins: redness, phlebitis, thrombosis; allergic reactions, including bronchospasm. If you exceed the speed of the introduction of the drug chills may occur, nausea, vomiting, kidney aminoatsidoz.
Recommended daily monitoring of the catheter insertion site.
Interaction with other drugs
Do not mix with drugs that are not intended for parenteral nutrition.
Note The features and characteristics of the medical use of the drug by pregnant women, women during the period of breastfeeding, children, adults with chronic diseases:
Use during pregnancy is possible only in those situations where the potential benefits of the testosterone propionate vs enanthate drug than the potential risk to the fetus.
During the period of lactation should abandon breastfeeding.
Information on the possible impact of the drug for medical use on the ability to drive vehicles, mechanisms
The drug has no negative impact on the ability to drive and perform other potentially hazardous activities that require high concentration and speed of psychomotor reactions.
The solution for infusion [for children].
In 20 ml of the drug in a neutral glass vial with a notch and a colored mark (dot).
On 5 vials are placed in contour cell substrate made of cardboard.
1 contour cell substrate together with instructions for use placed in a cardboard box.