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However, unlike these drugs, domperidone does not penetrate the blood-brain barrier. The use of domperidone, rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary. Its antiemetic effect, possibly due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone.
When used inside testosterone propionate side effects domperidone increases the antral and duodenal contraction, accelerates gastric emptying – yield of liquid and semi-solid fraction in healthy humans and solid fractions from patients in whom this process has been slowed down, and increases the pressure of the sphincter of the lower esophagus in healthy people. Domperidone has no effect on gastric secretion.

Pharmacokinetics
Domperidone is rapidly absorbed when administered orally on an empty stomach, the maximum observed plasma concentration for about 30-60 minutes. The low absolute bioavailability of oral route domperidone (approximately 15%) due to extensive initial metabolism in the intestinal wall and liver.
Although healthy bioavailability of domperidone is increased when given after a meal, patients with complaints of the gastrointestinal tract should be domperidone 15 -30 minutes before a meal. Hypoacid gastric juice reduces the absorption of domperidone. Before the drug after meals for maximum absorption takes more time, and the area under the curve (AUC) increases slightly.
If oral domperidone does not accumulates and does not induce its own metabolism; maximum plasma concentration at 90 min after administration, equal to 21 ng / ml after two weeks oral administration of 30 mg per day was almost the same as after the first dose (18 ng / ml). Domperidone is 91-93% bound to plasma proteins.
The drug is metabolized in the liver by hydroxylation and N- dealkylation. When in vitro drug metabolism studies with diagnostic inhibitors was found that CYP3A4 is a major form of cytochrome-450 enzymes involved in the N-dealkylation of domperidone, whereas CYP3A4, CYP1A2 and CYP2E1 involved in the process of hydroxylation of aromatic domperidone. Excretion of urine and feces was 31 and 66% of the oral dose, respectively. Isolation of the drug in an unmodified form of a small percentage (10% – in the feces and about 1% – in the urine). Plasma half-life period after administration of a single dose is 7-9 hours in healthy people, but lengthened in patients with severe renal insufficiency.

Indications In adults: a) Complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux and esophagitis:

feeling of fullness in the epigastrium, sense of abdominal distention, pain in the upper abdomen;
belching, flatulence;
nausea, vomiting;
heartburn, belching.
b) Nausea and vomiting of functional, organic, infectious origin caused by radiotherapy, drug therapy, or violation of the diet. A specific indication is nausea and vomiting caused by dopamine agonists in the event of their application in Parkinson’s disease (such as L-dopa and bromocriptine). In pediatric patients the drug is indicated for regurgitation syndrome, cyclic vomiting, gastro-oesophageal reflux disease and other gastric motility disorders.Contraindications
installed intolerance of the drug and its components.
prolactin-secreting pituitary tumor (prolactinoma).
concomitant use of oral forms of ketoconazole (See Interactions. section)
gastrointestinal bleeding, mechanical obstruction or perforation (t. e. when the stimulation of gastric motility might be dangerous)Dosing and Administration1. Chronic dyspepsia Adults: 10 mg (1 tablet or 10 ml) 3 times a day for 15-30 min. before meals and, if necessary, before bedtime. The maximum daily dose – 80 mg. Children: 2.5 ml of suspension for oral administration for 10 kg body weight (ie, 0.25 mg domperidone per 1 kg of body weight..), 3 times a day before meals and, if necessary before going to bed. If necessary, the specified dosage can be doubled (except for children under the age of 1 year). The maximum daily dose of domperidone – 2.4 mg per 1 kg of body weight, but not more than 80 mg.

2. Nausea and vomiting Adults: 20 mg (2 tablets or 20 mL) 3-4 times a day before meals and at bedtime. The maximum daily dose – 80 mg. Children: 5 ml oral suspension for 10 kg of body weight (ie 0.5 mg domperidone per 1 kg of body weight..), 3-4 times a day before meals and at bedtime. This dose is achieved by filling the pipette twice. The maximum daily dose of domperidone -. 2.4 mg per 1 kg of body weight, but not more than 80 mg of Motilium tablets are shown only for adults and children weighing more than 35 kg in pediatric practice testosterone propionate side effects is mainly to use Motilium suspension. It is recommended for kidney failure reducing the frequency of drug administration (see. section Cautions).

DIRECTIONS FOR USE bottle before use should be shaken. The suspension packaging, protected against accidental opening of the children. The bottle should be opened as follows:
Push down on the plastic cover of the vial, while turning it counterclockwise.
Remove the unscrewed cap. Pipette (available only with the 100 ml bottle)
Remove the pipette from the case and place it in a vial.
Hold in place the lower ring, lift the top up to the mark corresponding to the weight of your child in kg.
Hold the bottom of the ring, remove the filled pipette from the bottle.
Empty the pipette and place it back in the holster.Close the bottle.Side effects
Gastrointestinal: gastrointestinal disorders (rare) occasion – transient intestinal cramps;
on the part of the nervous system: extrapyramidal effects (children-very rarely, in adults – single cases); these effects are completely reversible and disappear after discontinuation of the drug;
on the part of the immune system: allergic reaction (very rare);
with the skin: hives;
with the endocrine system: increase in the plasma level of prolactin caused by the fact that the pituitary is outside the blood-brain barrier;In rare cases this hyperprolactinaemia may stimulate the emergence of neuro-endocrine effects such as galactorrhoea, gynaecomastia and amenorrhoea.OverdoseSymptoms
Symptoms of overdose may include: drowsiness, disorientation and extrapyramidal reactions, especially in children.

Treatment
In case of overdose, it is recommended the use of activated charcoal and close observation. Anticholinergic agents, drugs used for the treatment of Parkinson’s disease, or antihistamines can be effective in extrapyramidal reactions.

Interaction with other drugs
Anticholinergic drugs can neutralize the effect of Motilium.
The oral bioavailability is reduced Motilium after previous receiving cimetidine or sodium bicarbonate. Do not take antacids and antisecretory drugs simultaneously with Motilium, as they reduce its bioavailability after oral administration (see also Warnings and Precautions.).
The main route of metabolic transformations of domperidone – through of CYP3A4. Based on in vitro studies suggest that simultaneous reception using drugs domperidone significantly inhibiting this enzyme, may cause an increase in plasma levels of domperidone. In conducting studies (healthy volunteers) reacting domperidone ketoconazole found that ketoconazole inhibits SYRZA4 dependent primary metabolism domperidone, thereby achieving approximately threefold increase in the maximum concentration of domperidone and AUC in the plateau phase.
Examples of inhibitors of the enzyme CYP3A4 is the following medications:
antifungals azole;
macrolide antibiotics;
HIV protease inhibitors;
nefazodone.
In investigating the interaction testosterone propionate side effects of domperidone and ketoconazole shown that the combined use of domperidone 10 mg four times a day and ketoconazole at a dose of 200 mg 2 times daily lengthening QT interval observed by 10-20 msec. Monotherapy domperidone in similar doses and when receiving a daily dose of 160 mg (that is 2 times greater than the maximum daily dose), there were no clinically significant changes in QT interval.
Theoretically, since Motilium has gastrokinetic action, it could affect the absorption of both an oral preparations, particularly sustained release formulations of active substances, or preparations enterorastvorimoy coated shell. However, the use of domperidone in patients while taking paracetamol or selected treatment with digoxin did not affect the levels of these drugs in the blood.
Motilium can also be combined with:
neuroleptics, the action of which it does not increase
agonists of dopaminergic receptors (bromocriptine, L-dopa), whose unwanted peripheral effects such as digestive disorders, nausea, vomiting, it inhibits without neutralizing their basic properties.Cautions
When combined with the use of Motilium antacid or antisecretory drugs should be taken after the last meal and not before meals, ie should not be taken simultaneously with Motilium. Use in infants Due to the fact that the metabolic functions and the blood-brain barrier in the first months of life are not fully developed, children, infants should be given either the drug very cautiously and under close medical supervision. Since the typical absence of neurological Motilium action is mainly the result of a weak passage through the blood-brain barrier, the occurrence of neurological symptoms can not be excluded in children under the age of 1 year. Overdose can cause neurological side effects in children The use of liver diseases Given the high degree of metabolism of domperidone in the liver, it should be used with caution Motilium in patients with hepatic impairment. Use in kidney disease patients with severe renal insufficiency (serum creatinine> 6 mg / 100 ml, i.e.> 0.6 mmol / l) increased the half-life of domperidone from 7.4 to 20.8 hours, but plasma concentrations were lower than in healthy volunteers. Since a very small percentage of the drug is excreted by the kidneys in an unmodified form, it is hardly necessary correction of a single dose in patients with renal insufficiency. However, with repeated administration of assigning frequency should be reduced to one or two times a day, depending on severity of disease, and may also be necessary to reduce the dose. In patients with prolonged therapy should be regularly monitored.

Use during pregnancy and lactation
Data on the use of domperidone during pregnancy is not enough. To date there is no evidence of an increased risk of malformations in humans. However, Motilium be administered during pregnancy only when its use is justified expected therapeutic benefit. Women domperidone concentration in breast milk is from 10 to 50% of the corresponding plasma concentrations and less than 10 ng / ml. The total amount of domperidone excreted in breast milk – less than 7 micrograms per day in the application of the maximum permissible dose of domperidone. It is unknown whether this level has a negative effect on infants. In this regard, the application of Motilium during lactation should stop breastfeeding.

Effects on ability to drive and operate machinery
Motilium has no effect on ability to drive and operate machinery.

Method of production
of 10 or 30 tablets from a blister hsloynoy 3-transparent film (PVC / LDPE / PVDC), and aluminum foil. 1 blister with instructions for use in a cardboard box.
Bottles of 100 or 200 ml of a suspension for oral administration of 0.1%, with a graduated pipette 5 ml or 10 ml of a measured cap.

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Increases the duration of peristaltic contractions of the antrum of the stomach and duodenum, accelerates gastric emptying, when the retardation of the process, increases the tone of the lower esophageal sphincter, eliminates the development of nausea and vomiting.
Domperidone does not penetrate the blood-brain barrier, so the use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but propionate testosterone domperidone stimulates prolactin release from the pituitary. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone. Domperidone has no effect on gastric secretion. Pharmacokinetics Absorption after oral administration on an empty stomach – fast (reception after eating, decreased gastric acidity slow down and reduce absorption). Maximum plasma concentration (TC max ) – 1 hour Bioavailability -. 15% (the effect of “first pass” through the liver). Communication with plasma proteins – 90%. Penetrates into various tissues, poorly cross the blood brain barrier (BBB). It is metabolized in the liver and in the intestinal wall (by hydroxylation and N-dealkylation). Displayed through the intestines of 66%, the kidneys – 33%, including unaltered – 1 and 10%, respectively. The half-life (T1 / 2) – 7-9 hours, with severe chronic renal failure (CRF) – lengthened.

Indications

a) Kompeks dyspeptic symptoms, often associated with delayed gastric emptying, gastro – esophageal reflux, esophagitis;
– feeling of fullness in the epigastrium, sense of abdominal distention, pain in the upper abdomen:
– belching, flatulence:
– heartburn with reflux or without casting of gastric contents into the oral cavity.
b) Nausea and vomiting functional, organic, infectious origin caused by radiotherapy, drug therapy or diet disorders, as well as dopamine agonists for the background in the case of their use in Parkinson’s disease (such as L-dopa and bromocriptine)

Pregnancy and lactation

Use of the drug in the I trimester of pregnancy is possible only when the expected benefit of therapy to the mother outweighs the potential risk to the fetus. To date there is no evidence of an increased risk of malformations in humans. Women domperidone concentration in breast milk is 4 times lower than corresponding concentrations in plasma. It is unknown whether propionate testosterone domperidone in this concentration has a negative impact on infants. Therefore, the use Motilak not recommended during lactation (breastfeeding), except in cases when the expected benefit of therapy to the mother outweighs the potential risk to the infant.

Contraindications

Hypersensitivity, bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, infancy (up to 5 years of age and for children weighing up to 20 kg).

dosage

Tablets: should dissolve in 15-20 minutes before eating. Adults and children over 5 years with chronic dyspeptic phenomena – 10 mg 3-4 times a day and, if necessary, further bedtime. In severe nausea and vomiting -. 20 mg 3-4 times a day and at bedtime
to patients with renal failure dose adjustment is necessary, frequency of intake should not exceed 1-2 times during the day.

Side effect

From the digestive system: transient intestinal cramps. Nervous system: extrapyramidal disorder (in children and patients with increased permeability of the BBB). Allergic reactions: skin rash, urticaria.Other: hyperprolactinemia (galactorrhea, gynecomastia).

Interaction

Cimetidine, sodium bicarbonate reduces the bioavailability of domperidone.
Anticholinergic and antacid drugs (PM) neutralize domperidone.
Increase the concentration of domperidone in the plasma. Antifungal drugs azole, macrolide antibiotics, HIV protease inhibitors, nefazodone (antidepressant)
compatible with the reception antipsychotic drugs (neuroleptics), agonists of dopaminergic receptors (bromocriptine, L-dopa).
Simultaneous treatment with paracetamol and digoxin had no effect on the concentration of these drugs in the blood.

Precautions
Renal / hepatic propionate testosterone insufficiency, during lactation, pregnancy.

Overdose

Symptoms: drowsiness, disorientation, extrapyramidal disorder (especially in children).
Treatment: reception activated carbon, with extrapyramidal disorders – anticholinergic drugs, antihistamines or antiparkinsonian drugs with anticholinergic properties. anabolic steroids online pharmacy

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Activates endogenous antinociceptive system and thus gives interneuronal transmission of pain impulses at different levels of the central nervous system and alter emotional pain by acting on the higher parts of the brain.
Morphine increases the pain threshold when stimuli of different modality, inhibits conditioned reflexes, has a euphoric and mild sedative effect, increases the tone of the center of the vagus nerve, inhibits the center of vomiting, can stimulate chemoreceptors trigger zone of the vomiting center, depresses the respiratory center, causing constriction of the pupil due to activation the center of the oculomotor nerve, increases the tone of the smooth muscle of the buy testosterone propionate bronchi and sphincters of the internal organs (intestines, biliary tract, urinary bladder), enhances the contractile activity of myo-meters, weakens the intestinal peristalsis, inhibits the secretory activity of glands of the gastrointestinal tract. Several reduced basal metabolic rate and body temperature, it stimulates the secretion of antidiuretic hormone. It causes dilation of peripheral blood vessels and the release of histamine, which can result in reduced blood pressure, skin redness, increased sweating, redness of the eyes of the protein. When administered subcutaneously effect develops in 10-20 minutes and lasts for 3-5 hours.
It is addictive and the drug (opioid) dependence (morphinism).

Indications for use
Morphine is used as an anesthetic in severe pain syndrome traumatic origin, in the preoperative, operative and postoperative periods, myocardial infarction, severe attacks of angina, pain in malignant formations and other conditions involving severe pain.

Contraindications
: Hypersensitivity to opiates.
State, accompanied by respiratory depression or severe depression of the central nervous system. Spasmodic state. Increased intracranial pressure. Head injuries. Acute alcoholic state and alcoholic psychosis. Bronchial asthma. Paralytic ileus. Heart failure due to chronic lung disease. Cardiac arrhythmias. Acute surgical diseases of the abdominal cavity before the diagnosis. Status after surgery on the biliary tract. Do not use morphine during treatment with monoamine oxidase inhibitors (MAOIs), and for an additional 14 days after their cancellation.

Application with caution
Chronic obstructive pulmonary disease, drug dependency (including history), alcoholism, suicidal tendencies, emotional lability, gallstone disease, surgery on the gastrointestinal tract, urinary system, liver or kidney failure, hypothyroidism, heavy inflammatory bowel disease, prostatic hypertrophy, urethral stricture, epileptic syndrome.
Common serious condition of the patient, elderly, children’s age.

Pregnancy and lactation
During pregnancy, childbirth and breastfeeding morphine application only permissible for health reasons (possible development of drug dependence in the fetus and newborn).

Dosing and Administration
Morphine administered subcutaneously. Doses are selected individually depending on the age and condition of the patient. Adults: the usual dose for adults under the skin – to 1 ml of 10 mg / ml. The analgesic effect develops within 10-15 minutes, reaching a maximum after 1-2 hours and lasts for 8 – 12 hours or more Higher doses for adults under the skin: single 0.02 grams daily 0.05 g Babies from birth up to 2 years Subcutaneous 100 – 200 mg / kg (0.1 – 0.2 mg / kg) as necessary every 4-6 hours, so that the total dose does not exceed 15 mg. Children older than 2 years Subcutaneous 100 – 200 mg / kg (0.1 – 0.2 mg / kg) as necessary every 4-6 hours, so that the total dose does not exceed 1.5 mg / kg body weight

Side effect From the digestive system: more often – nausea and vomiting (usually at the beginning of therapy), constipation; less often – dry mouth, anorexia, biliary tract spasm, cholestasis (in the main bile duct), gastralgia, stomach cramps; rarely – gepatotok-sichnost (dark urine, pale stools, hysteria sclera and skin), with severe inflammatory bowel disease – intestinal atony, paralytic buy testosterone propionate ileus, toxic megacolon (constipation, flatulence, nausea, stomach cramps, vomiting). On the side cardiovascular system: more frequent – lowering blood pressure, tachycardia, less often – bradycardia, the frequency is not known – high blood pressure. The respiratory system: more often – depression of the respiratory center, less often – bronchospasm, atelectasis. From the nervous system: more often – dizziness, fainting, drowsiness, unusual tiredness, weakness; less often – headache, tremor, involuntary muscle twitching, discoordination muscle movements, paresthesia, anxiety, depression, confusion (hallucinations, depersonalization), increased intracranial pressure with a probability of subsequent ischemic attacks, insomnia; seldom – a restless sleep, depression of the central nervous system, on the background of large doses – muscle stiffness (especially respiratory), in children – paradoxical excitement, restlessness; the frequency is unknown – cramp, nightmares, sedative or stimulating effect (especially in elderly patients), delirium, decreased ability to concentrate. With the genitourinary system: less often – reduced urine output, spasm of the ureters (difficulty and pain when urinating, frequent urge to urinate), reduced libido, reduced potency; the frequency is unknown – a spasm of the sphincter of the bladder, a violation of the outflow of urine, or aggravation of the condition in prostatic hyperplasia and stenosis of the urethra. Allergic reactions: more often – wheezing, facial flushing, rash, facial skin; less often – skin rash, hives, itching, swelling of the face, swelling of the trachea, laryngeal spasm, fever. Local reactions: redness, swelling, burning sensation at the injection site. The other: more often – sweating, hoarseness; less frequently – a violation of sharpness of vision (including diplopia), miosis, nystagmus, an imaginary feeling of well-being, a sense of discomfort; the frequency is unknown – tinnitus, drug dependence and tolerance, “cancellation” syndrome (muscle pain, diarrhea, tachycardia, mydriasis, pyrexia, rhinitis, sneezing, sweating, yawning, aioreksiya, nausea, vomiting, nervousness, fatigue, irritability, tremors, stomach cramps, fatigue, hypoxia, muscle contraction, headache, increased blood pressure and other autonomic symptoms). repeated use of morphine in techetsie 1-2 weeks (sometimes for 2-3 days may develop addiction (weakening of the analgesic effect) and opioid drug dependence.

Overdose
If overdose or poisoning develops stuporous or comatose, hypothermia, lowering blood pressure, there is respiratory depression. A characteristic feature is a pronounced constriction of the pupils (pupils with significant hypoxia may be extended).
First aid for poisoning – Maintenance of adequate pulmonary ventilation Intravenous administration of a specific opioid antagonist naloxone at a dose of 0.4 to 2 mg quickly restores breathing. If no effect within 2-3 minutes of administration of naloxone is repeated. The initial dose of naloxone for children – 0.01 mg / kg. Nalorphine may be used: 5.10 mg intramuscularly or intravenously every 15 minutes to a total dose of 40 mg. It is necessary to consider the possibility of a withdrawal syndrome when administered naloxone and nalorphine patients with addiction to morphine – in such cases the dose should be increased gradually antagonists.

Interaction
Enhances the effect of buy testosterone propionate hypnotics, sedatives, mestnoanesteziruyuschih drugs, drugs for general anesthesia and anxiolytics.
Ethanol, muscle relaxants, and drugs that suppress the central nervous system, enhance deprimiruyuschie effects and respiratory depression.
Buprenorphine (including prior therapy) reduces the effect of other opioid analgesics; during treatment with high doses of agonists of the mu-opioid receptor reduces respiratory depression, and during treatment with low doses of agonists mu or kappa opioid receptor – strengthens; accelerates the emergence of symptoms of “withdrawal” upon discontinuance of the agonists of mu-opioid receptors in the background of drug dependence, with their sudden abolition partially reduces the severity of symptoms. The systematic admission of barbiturates, especially phenobarbital, there is the possibility of reducing the severity of analgesic effect of narcotic analgesics, stimulates the development of cross-tolerance.
When concomitantly with beta-blockers may increase the inhibitory action on the central nervous system with dopamine – a decrease in analgesic effect of morphine, cimetidine – strengthening respiratory depression, with other opioid analgesics -. central nervous system depression, respiratory depression, decreased blood pressure
Chlorpromazine strengthens myotic, sedative and analgesic effects of morphine.
phenothiazines and barbiturates increase the hypotensive effect and increases the risk of respiratory depression.
Naloxone reduces the effect of opioid analgesics, and as they cause respiratory depression and central nervous system; may require higher doses to the leveling effects of butorphanol, nalbuphine and pentazocine, who were appointed to eliminate the adverse effects of other opioids; can accelerate the emergence of symptoms of “withdrawal” on the background of drug addiction.
Naltrexone accelerates the appearance of symptoms of “withdrawal” on the background of drug dependence (symptoms may appear within 5 minutes after administration, continued for 48 hours, characterized by stability and the difficulty of their elimination) ; reduces the effect of opioid analgesics (analgesic, antidiarrheal, anti-cough); no effect on symptoms caused by histamine response. Nalorfin eliminates the respiratory depression caused by morphine.
Enhances the hypotensive effect of drugs that lower blood pressure (including ganglioblokatorov, diuretics).
Competitive inhibits hepatic metabolism of zidovudine and reduces its clearance (increased risk of mutual intoxication).
Drugs with aptiholinergicheskoy activity, antidiarrheal drugs (including loperachid) increase the risk of constipation until the ileus, urinary retention, and depression of the central nervous system. It reduces the effect of metoclopramide.

Cautions
With careful use of morphine in elderly patients, with general exhaustion, liver and kidney insufficiency adrenal cortex. Under close supervision and in small doses should be used morphine on a background of action of drugs acting on the central nervous system (anesthetic drugs, hypnotics, anxiolytics, antidepressants, neuroleptics, anti-histamine, and other non-narcotic pain medications) to prevent excessive depression of the central nervous system ., and the suppression of the respiratory center active
drug should not be combined with narcotic analgesics from the group of partial agonists (buprenorphine) and agonists – antagonists (nalbuphine, butorphanol, tramadol) opioid receptors because of the risk of weakening of analgesia and the possibility of provoking a withdrawal syndrome in patients with addiction to opioids . The analgesic effect and the undesirable effects of opioid agonists (trimeperidine, fentanyl) in therapeutic doses of morphine are added to the effects. During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions, prevent the use of ethanol.
Do not use in situations where it may cause paralytic ileus. With the threat of occurrence of paralytic ileus use of morphine should be stopped immediately.
In patients with suspected heart surgery or other surgery with intense pain, the use of morphine should be discontinued 24 hours before surgery. If you later therapy is indicated, the dosage regimen is selected based on the severity of the operation.
Sometimes there may be tolerance and dependence on the drug. If you have nausea and vomiting can be used with a combination of phenothiazine. To reduce the side effects of morphine drugs in the intestine should be used laxatives.
It should be borne in mind that children under 2 years of age are more susceptible to the effects buy testosterone propionate of opioid analgesics, and they can have paradoxical reactions.

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Combination drug whose action is due to a complex of essential amino acids and vitamins in a balanced proportion of its constituent.

The complex is designed to accelerate the regeneration of the structural components of cells, normalizes metabolism, stimulate the immune defense of the body. Helps prevent age-related changes in the body, accelerate the recovery of health during convalescence and / or fatigue, reduces the damaging effect testosterone propionate half life of environmental factors, it prevents the effects of vitamin A deficiency. Thanks to a special granulation technology bioavailability reaches 98%.

The functional significance and influence of the essential amino acids:

L-isoleucine – is required for formation of hemoglobin and normal skin growth. It stabilizes and regulates blood sugar levels. It accelerates the process of energy production, increases stamina and helps to restore muscle tissue. Of L-leucine – an energy source at the cellular level. It contributes to the restoration of bones and tissues. Of particular importance in the recovery period after surgery, diseases, injuries. Of L-lysine hydrochloride – is involved in the production of hormones, enzymes, promotes the formation of collagen. Essential for normal formation and bone growth in children. It promotes the absorption of calcium in adults. Has expressed an antiviral effect. Of L-phenylalanine – regulates the function of the thyroid gland. It promotes higher mental functions. It has a mild antidepressant effect.Increases efficiency. Of L-threonine – participates in the formation of collagen and elastin. Has lipotropic properties it helps prevent fatty liver. It activates the body’s immune system. Prevents the development of fatty liver disease. L-tryptophan – involved in the synthesis of albumin and globulin, accelerates the release of growth hormone. It has antidepressant effects. It promotes relaxation and good sleep. It increases resistance to stress. It helps to reduce the negative effects of nicotine. L-valine – is necessary to normalize metabolism in muscle tissue repair and maintenance of nitrogen balance in the body. It is used in the treatment of multiple sclerosis as a means mielinezatsii. Used in the treatment of diseases that lead to amino acid deficiency (drug addiction, alcoholism, smoking). Of L-methionine – has hepatoprotective action. It activates the action of hormones, vitamins and enzymes. It lowers blood cholesterol concentrations and increases the content of phospholipids. It protects against radiation exposure. 5 hydroxyanthranilic acid hydrochloride – is a factor activating the essential amino acids using vitamins to participate in protein biosynthesis.

The functional significance of vitamins:

Ascorbic acid – essential for normal glucose uptake and glycogen formation in the liver. Involved in synthesis of hormones that regulate blood clotting in the exchange of tyrosine. Applied for the prevention of hypovitaminosis, speed up adaptation to new climatic conditions, as well as for the prevention and treatment of colds and infectious diseases. Ergocalciferol – regulates phosphorous and calcium metabolism in the body, promotes the absorption of these substances intestine and timely deposition of their growing bones. It is essential for the formation of bone tissue of the fetus. Nikotinamidm – involved in the metabolism of fats, proteins, amino acids, purines, tissue respiration. It is used for prevention and treatment of diseases of the liver, gastrointestinal tract, atherosclerosis, healing of burns and wounds.Pyridoxine hydrochloride – is involved in the processes of carbohydrate metabolism, the synthesis of hemoglobin and polyunsaturated fatty acids. Suitable for intense physical and mental stress. Retinol Palmitate – is involved in redox processes, regulation of protein synthesis. It is necessary for the growth of new cells slows down the aging process. Used testosterone cypionate half life for the prevention of colds and infectious diseases.Riboflavin – participates in the process of cellular respiration, it affects all kinds of metabolic processes. A particularly important role in providing visual functions, the normal state of the skin and mucous membranes, the synthesis of hemoglobin. Used in the treatment of states of overvoltage and anemia. Thiamine mononitrate – has been actively involved in many metabolic processes and affects the operation of virtually every cell of the body is necessary for normal brain function, as normalizes cerebral circulation, and in addition, participates in blood formation processes . Reduces the negative effects of alcohol and tobacco, it protects the body from infectious agents and also slows the aging process. Alpha-tocopherol acetate – improves blood circulation, is necessary for tissue regeneration. It is used in treatment of premenstrual syndrome and the fibrotic breast disease. It ensures normal blood clotting and healing. Possess strong antioxidant properties. Calcium pantothenate – plays an important role in the process of acetylation and oxidation involved in carbohydrate and lipid metabolism, the synthesis of acetylcholine, a steroid hormone and cholesterol. Adjust the height and weight, has beneficial effects on the nervous system. It reduces the risk of cardiovascular and gastrointestinal diseases. Cyanocobalamin – is important in hematopoiesis processes. In combination with folic acid contributes to the maturation of red blood cells. It provides the normal growth of the organism. It has a positive effect on the heart muscle, has anti-allergic and analgesic properties. Folic acid – essential for normal hematopoiesis, plays an important role in cell division. Participates in the formation of the placenta, ensures the growth and development of the fetus. It improves mental and physical performance.

Indications for use:

Prevention and replenishing amino acids and vitamins deficiency (the period of rapid growth in childhood and adolescence, pregnancy, grudovskarmlivanie (breast-feeding, breast vskarmlmvanie), advanced age)
Restoration of structural components of cells / restore metabolism (skin aging, increased fragility of nails, a change in the structure of hair)
Increased physical and mental stress, chronic fatigue cider
Recovery / recovery period after illness, injury, surgery, after taking antibiotics;
Malnutrition (including diet designed to reduce body mass);
Gastrointestinal disease (in combination therapy) (gastritis, enteritis, colitis, etc.);
(In the complex therapy) liver disease (hepatitis, cirrhosis, fatty degeneration)
(In the treatment of chronic kidney disease (nephropathy)
(In the complex therapy) cancer (improves efficiency and facilitates the portability of radiation and chemotherapy)
(In the complex therapy) male infertility (spermatogenesis disorder)

Contraindications:

Hypersensitivity to the drug;
Children under 3 years of age;
hypervitaminosis;

Dosage and administration:

Inside, regardless of meals, drinking plenty of water. If it is impossible to swallow capsules whole allowed to stir Contents of warm water, milk or liquid food, having a neutral environment. The granule mix is taken immediately, its storage testosterone propionate half life (without the capsule shell) is unacceptable.

For prevention:

From 3 to 6 years appoint 1 capsule per day;
Children older than 6 years and adults – 2 capsules per day;

Preventive course of not less than 3 months. If necessary, it may be continued or repeated.

For the treatment of:

Children from 3 to 6 years old – 1 capsule per day;
From 6 to 12 years – 2 capsules 3 times a day;
Children over 12 and adults appoint 1-2 capsules 3 times a day;

The treatment course is not less than 2 months and may be extended or repeated as necessary.

During pregnancy:

In the I trimester – 1 capsule per day;
In II and III trimester appointed to 2 capsules per day;

Side effects:

Allergic reactions to components of the preparation

Overdose:

In case of overdose, seek medical attention. Treatment: a temporary cessation of the drug, gastric lavage, activated charcoal, symptomatic therapy.

Interaction with other drugs:

Ascorbic acid slows down barbiturates, salicylates, sulfonamides;
Pyridoxine hydrochloride, levodopa decarboxylation increases in peripheral tissues;
Isoniazid reduces the effectiveness of pyridoxine;
Oral contraceptives (estrogens) increase in serum concentration of retinol palmitate and ascorbic acid, folic acid reduces the concentration;

Special instructions:

Do not use concomitantly with other drugs containing vitamins. In diabetes drug is recommended after consultation with a doctor. oxydrolone

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testosterone propionate vs enanthate

08/31/2016 admin

When administered intravenously, the bioavailability is 100%. Amino acids are distributed in the interstitial fluid and extracellular space of tissues and organs. When testosterone propionate vs enanthate properly administered does not disturb the balance of amino acids. A small portion of the amino acid is eliminated by the kidneys.

Indications for use:

Partial or total parenteral nutrition in children under 5 years in conjunction with the carbohydrate solution, fat emulsion preparations and vitamins, electrolytes and trace elements (including when enteral nutrition is impossible or insufficient). If necessary, use an additional baby taurinsoderzhaschie drugs.

Contraindications for use:

Violation of amino acid metabolism, metabolic acidosis, hyperhydration, hypokalemia, shock, hypoxia, decompensated heart failure, hypersensitivity to the drug.

dosing regimen, the route of administration

Slowly injected intravenously (drip), preferably in the central vein at a rate of 2 ml / min (maximum of 40 drops per minute).

Allowed infusional drug together with a 5% glucose solution: the contents 2 – 3 ampoules testosterone propionate vs enanthate (according to the doctor’s prescription) was diluted in 200 ml of 5% glucose solution and administered at a rate of 25 – 35 drops per minute.

The maximum daily dose: Children aged 2 – amino 1.5-2.5 g per 1 kg of body weight, or from 25 ml to 40 ml S-2 per 1 kg of body weight per day; children over 2 years of age – 2.5 g of amino acids per 1 kg of body weight, or 25 ml per 1 kg of body weight per day.

In catabolic states – 1.3-2 g amino acids per kg / day.

The drug is administered as long as the need for parenteral nutrition.

Precautions for use

Use with caution in patients with renal / hepatic insufficiency.

Special instructions:

In parenteral nutrition of young children the following parameters must be considered: urea nitrogen, ammonia, glucose, electrolytes, triglycerides (for additional administration of fat emulsions), the activity of “liver” enzymes, serum osmolarity, acid-base balance and water-salt metabolism.

Too rapid infusion could result in loss of amino acids through the kidneys, and thus, to the amino acid imbalance.

Amino acids contained in the product can become a breeding ground for microorganisms, and therefore the equipment for intravenous infusion should be thoroughly sterilized.

Overdose symptoms, relief measures in overdose

In excess doses may experience acute circulatory disorders. In this case, the introduction of the drug should be discontinued immediately.

Possible side effects when using the drug

When infusion of the drug signs of local reactions may be observed in the peripheral veins: redness, phlebitis, thrombosis; allergic reactions, including bronchospasm. If you exceed the speed of the introduction of the drug chills may occur, nausea, vomiting, kidney aminoatsidoz.

Recommended daily monitoring of the catheter insertion site.

Interaction with other drugs

Do not mix with drugs that are not intended for parenteral nutrition.

Note The features and characteristics of the medical use of the drug by pregnant women, women during the period of breastfeeding, children, adults with chronic diseases:

Use during pregnancy is possible only in those situations where the potential benefits of the testosterone propionate vs enanthate drug than the potential risk to the fetus.

During the period of lactation should abandon breastfeeding.

Information on the possible impact of the drug for medical use on the ability to drive vehicles, mechanisms
The drug has no negative impact on the ability to drive and perform other potentially hazardous activities that require high concentration and speed of psychomotor reactions.

release Form

The solution for infusion [for children].
In 20 ml of the drug in a neutral glass vial with a notch and a colored mark (dot).
On 5 vials are placed in contour cell substrate made of cardboard.
1 contour cell substrate together with instructions for use placed in a cardboard box.

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