Category Archives: bodybuilding proqrami

testosterone cypionate vs propionate

It has vasodilating and antianginal effects. Reduces preload (through the expansion of peripheral veins) and afterload (due to a decrease in total peripheral vascular resistance) reduces the myocardial oxygen demand, increases coronary artery and improves coronary blood flow, contributes to its redistribution in the ischemic area, reduces end-diastolic volume of the left ventricle and reduced systolic tension of its walls. Increases exercise tolerance in patients with coronary heart disease, lowers blood pressure in the testosterone cypionate vs propionate pulmonary circulation.
Isosorbide mononitrate is relaxation of the muscles of the bronchi, the urinary tract, muscle of the gallbladder, biliary tract and esophagus, as well as small and large intestines, including the sphincters.
The drug is rapidly and completely absorbed in the intestine after ingestion. Bioavailability is 90 to 100%. There is a direct relationship between blood concentration of the drug dose received. Isosorbide mononitrate is derived almost exclusively via the kidneys as metabolites. Approximately 2% is excreted unchanged. The half-life is 4-5 hours.

Indications

 

  • Prevention of angina attacks.
  • Treatment of chronic heart failure in combination with cardiac glycosides, diuretics, ACE inhibitors, arterial vasodilators.-Increase The pressure in the pulmonary circulation (pulmonary hypertension).Contraindications
  • hypersensitivity to organic nitrates
  • acute circulatory disorders (shock, circulatory collapse)
  • cardiogenic shock, if you do not provide a sufficiently high end-diastolic pressure in the left ventricle through the use of intra-aortic counterpulsation or by the administration of drugs that have a positive inotropic effect
  • concomitant use of phosphodiesterase inhibitor sildenafil (of Viagra ® , Viagra), because sildenafil potentiates the antihypertensive effect of nitrates
  • severe hypotension (systolic blood pressure less than 90 mm Hg, diastolic blood pressure less than 60 mmHg)
  • hemorrhagic stroke, angle-closure glaucoma, traumatic brain injury, hyperthyroidism, idiopathic hypertrophic subaoralny stenosis, deficiency of glucose-6-phosphate dehydrogenase, liver and kidney failure, age 18 years
    Monolong should be taken with caution in the following cases:
  • constrictive pericarditis, pericardial tamponade
  • low filling pressure in acute myocardial infarction, impaired function of the left chamber of the heart (left ventricular failure). There should be no reduction in systolic blood pressure below 90 mm Hg
  • aortic and / or mitral stenosis, a tendency to orthostatic vascular disorders of regulation expressed cerebral atherosclerosis, diseases accompanied by intracranial hypertension
    Monolong should not be used for the relief of acute attacks of angina and acute myocardial infarction.Pregnancy and lactation
    For security reasons Monolong can be used during pregnancy and lactation only if the benefit to the mother outweighs the potential risk to the fetus / child, because to date, little is known about the consequences of its use in pregnant testosterone cypionate vs propionate women and lactating mothers.

    Effects on ability to drive and use machines
    During treatment is not recommended to drive vehicles and doing other potentially hazardous activities that require a rapid psychomotor reactions.
    In the period of treatment should be deleted alcohol.

    Dosage and administration
    Capsules swallowed whole with water. For a more rapid absorption of the drug it is preferred to take 1 hour or 2 hours after meals.
    The dosage should be adjusted according to the characteristics and tolerability individual patients. With the deterioration of the patient, or reducing the effectiveness of the drug may need to increase the dose.
    Treatment is recommended to start with the lowest dosage form containing isosorbide mononitrate, that is 40 mg once a day. If the dose is insufficient – it is possible to increase the 1 to 60 mg once daily.
    In rare cases, the dose can be increased to 80 mg per day (2 capsules of 40 mg). The duration of treatment and increasing the dose determined by the physician. The efficacy and safety of the drug has not been established in children.

    Side effect
    “Nitrate” headache may occur at the beginning of treatment. With continued therapy, it usually decreases after a few days.
    After the first dose or after increasing the dose of the drug can occur lowering blood pressure and / or the development of orthostatic hypotension, which may be accompanied by tachycardia, dizziness, and weakness.
    May very rarely celebrated nausea, vomiting, redness . face and allergic skin reactions
    in rare cases, a pronounced reduction in blood pressure is accompanied by worsening angina (a paradoxical reaction to nitrates).
    occasionally there were cases collaptoid states, sometimes with bradyarrhythmia and syncope. Notes: Describes the development of tolerance, as well as cross-tolerance to other nitro compounds at long-term continuous treatment with high doses of isosorbide mononitrate. To prevent degradation or loss of effectiveness, to avoid continuous administration of high doses of the drug and drug administration more than 2 times per day. The use Monolonga can lead to transient hypoxia due to the relative blood flow redistribution gipoventiliruemye alveolar segments. It can be a trigger of ischemia in patients with coronary heart disease.

     

    Overdose Symptoms of overdose: Lowering blood pressure with orthostatic dysregulation, reflex tachycardia, and headache. May develop fatigue, dizziness, somnolence, sweating, hot flushes, nausea and vomiting, diarrhea hyperpnoea, dyspnea, bradycardia, increased intracranial pressure, paralysis, coma. In chronic overdose may cause a higher level of methemoglobin. Therapy with overdose In addition to general recommendations such as washing stomach and placing the patient in a horizontal position, legs raised high, with marked decrease srterialnogo pressure and / or patients in shock should be the introduction of fluid; in exceptional cases, to improve blood circulation can be performed infusion of norepinephrine and / or dopamine. Introduction of epinephrine and related compounds is contraindicated.When methemoglobinemia – intravenous injection of 1% methylene blue solution, 1.2 mg / kg.

    Interaction with other drugs
    When using with other vasodilators, antihypertensive drugs, beta-blockers, blockers “slow” calcium channel blockers, antipsychotics or tricyclic anti-depressants, amiodarone, a phosphodiesterase inhibitor sildenafil testosterone cypionate vs propionate and alcohol may potentiation of anti-anginal action drug.
    with the simultaneous introduction Monolonga and dihydroergotamine can occur raising dihydroergotamine and potentiation of the hypertensive action.
    The therapeutic effect of noradrenaline is reduced when taken with nitropreparatov.
    The combined use with M-holinoblokatorami (atropine, and others.) increases the likelihood of increased intraocular pressure .
    Adsorbents, binders and overlying means reduce the absorption of isosorbide mononitrate in the digestive tract.
    Under the influence of sympathomimetic alpha-blockers (dihydroergotamine, etc.) may reduce the severity of anti-anginal effect (excessive reduction in blood pressure and, as a consequence, coronary perfusion). Barbaturaty accelerate the metabolism and reduce the concentration of isosorbide mononitrate in the blood.

  and testosterone hcg injections for weight loss reviews prostate cancer

testosterone propionate results

Absorption testosterone propionate results negligible. After 8 hours after the single application on intact skin (without occlusive dressings) detected in the systemic circulation of about 0.4% of the active substance. Mometasone is extensively metabolized in the liver, kidneys displayed mainly in small quantities in the bile.

Indications
Inflammation and itching dermatoses with measurable glucocorticosteroid therapy.

Contraindications

  • Hypersensitivity to any component of the formulation or to the SCS.
  • Rosacea, perioral dermatitis.
  • Bacterial, viral (Herpes simplex, chicken pox, Herpes zoster), or a fungal infection of the skin.
  • Tuberculosis, syphilis.
  • Post-vaccination reactions.
  • Pregnancy (treatment of large areas of skin, long-term treatment).
  • Lactation (used in large doses and / or for a long time).

Carefully

  • Application to the skin of the face and intertriginous skin, the use of occlusive dressings, as well as the treatment of large areas of skin and / or long-term treatment (particularly in children).

Use during pregnancy and lactation
The safety of mometasone furoate during pregnancy and lactation has not been studied.
Corticosteroids cross the placental barrier. Avoid long-term treatment and the use of large doses during pregnancy due to the risk of negative impact on fetal development.
Corticosteroids are excreted in breast milk. In the case where the use of corticosteroids expected at high doses and / or for a long time, discontinue breastfeeding.

Dosage and administration:
Outwardly.
Cream Momat thin layer is applied to the affected skin once daily.
The duration of treatment is determined by its efficiency, as well as the tolerance of the patient, presence and severity of side effects.

Side effects:
Rarely – skin irritation and dryness, burning sensation, pruritus, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, the accession of secondary infection, signs of skin atrophy, striae, miliaria. Less than 1% of -. The formation of papules, pustules
When applying external shapes SSC for a long time and / or for the treatment of large areas testosterone propionate results of skin, or with occlusive dressings, especially in children and adolescents, the side effects characteristic of corticosteroids may occur systemic effects, including adrenal insufficiency and Cushing’s syndrome.

Overdose Symptoms : inhibition of the function of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency. Treatment : symptomatic, if necessary – correction of electrolyte imbalance, removal of the drug (for long-term treatment – phasing out).

Interaction with other drugs
cream drug interaction studies have not been conducted Momat with other drugs.

Cautions
When applied to large areas of the skin for a long time, especially in the application of occlusive dressings may develop corticosteroids systemic effects.
In view of this, patients should be observed for signs of suppression of the hypothalamic-pituitary-adrenal system and the development of Cushing’s syndrome.
Avoid getting cream Momat eyes.
Propylene glycol, which is part of the drug may cause irritation at the site of application. In such cases, discontinue use Momat cream and appropriate treatment.
It should be borne in mind that corticosteroids are able to change some of the manifestations of skin diseases that can complicate diagnosis. In addition, the use of corticosteroids may be the cause of the delay wound healing.
In long-term treatment of GCS sudden cessation of therapy can lead to rebound syndrome, which manifests itself in the form of dermatitis with intense redness and burning sensation. Therefore, after the long course of treatment abolition of the drug must be carried out gradually, for example, switching to intermittent treatment regimen before it is completely stopped. Paediatric use in connection with the fact that the children value surface testosterone propionate results area ratio and body mass is greater than in adults children are at greater risk of suppressing the function of the hypothalamic-pituitary-adrenal system and the development of Cushing’s syndrome when applying any topical corticosteroids. Long-term corticosteroids treatment of children can lead to violations of their growth and development. children should receive the minimum dose sufficient to achieve the effect. eminence labs

testosterone propionate buy

Selective imidazoline receptor agonists responsible for the reflex control of the sympathetic nervous system (localized in the ventral-lateral medulla). Slightly communicates with the central alpha2-adrenergic receptors reduces systolic and diastolic blood testosterone propionate buy pressure (BP) and after a single long-term use.

With long-term use reduces hypertrophy of the left ventricular myocardium, eliminates signs of myocardial fibrosis, mikroarteriopatii normalizes capillary blood flow to the myocardium, reduces the total peripheral vascular resistance, pulmonary vascular resistance, while cardiac output and heart rate (HR) did not change significantly. The treatment reduces the activity of norepinephrine and epinephrine, renin, angiotensin II at rest and during exercise, the atrial natriuretic peptide (load), and plasma aldosterone. Decreases Resistance to insulin by 21% compared to placebo in patients with obesity and insulin-resistant patients with moderate hypertension, it stimulates the release of growth hormone. It does not affect glucose metabolism and lipid.

Pharmacokinetics
Absorption.
Once inside quickly and almost completely absorbed from the gastrointestinal tract (about 90%). Eating on the amount of absorption is not affected. Maximum plasma concentration (Cmax) is reached after 30-180 minutes and after oral administration is 1-3 ng / ml. The interval between reaching Cmax and pronounced decrease in blood pressure at rest varies on average by 10%, with a load – by 7.7%. Duration -. The bioavailability of more than 12 hours after a single application of 88% inside, indicating no significant effect of “primary” passing through the liver.

Distribution.
It penetrates the blood-brain barrier. Not accumulates long-term use.
The volume of distribution – 1,4-3 l / kg. Communication plasma protein 7%.

Metabolism.
Metabolized 10-20% of moxonidine to form 4,5-degidromoksonidina and aminometanamidinovogo derivative.

. Elimination
half-life (T 1/2 ) is 2-3 hours in the first 24 hours the kidneys derived more than 90% (50-75% – unchanged, 20% – in the form of metabolites)., And about 1% – with bile. In testosterone propionate buy a small amount of Moxonidine appears in hemodialysis.

Special patient groups
Elderly age
No significant differences in pharmacokinetics in younger patients and elderly patients were found. Correction dose is not required under normal renal function.

Renal impairment
In patients with mild (creatinine clearance (CC) of 30-60 mL / min) and severe (creatinine clearance <30 mL / min) in violation of the plasma equilibrium concentration of kidney function and the final T 1/2about 2 or 3 times respectively higher than in hypertensive patients with normal renal function (creatinine clearance of> 90 ml / min). Therefore, patients with severe renal impairment is contraindicated drug, and with moderate kidney dysfunction drug should be used with caution, the dose should be individualized.

Abnormal liver function
no reliable trials of moxonidine in patients with impaired liver function no. Since moxonidine practically not metabolized in the liver, disturbance of its function does not have a pronounced effect on the pharmacokinetics of the drug.

Indications for use:

Arterial hypertension.

Contraindications:

 

  • hypersensitivity to moxonidine or any other component of the drug;
  • Hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
  • The expressed disturbances of heart rhythm (bradycardia (less than 50 beats / min at rest), sick sinus syndrome or sinoatrial block, atrioventricular block grade II and III);
  • Chronic heart failure (III-IV functional class NYHA classification);
  • severe renal insufficiency (creatinine clearance <30 mL / min creatinine concentration in the serum of> 160 mmol / l) and hemodialysis;
  • the simultaneous use of tricyclic antidepressants;
  • age of 18 years;
  • during breastfeeding.

 

Precautions
atrioventricular block of I degree (risk of bradycardia), coronary artery disease (including coronary heart disease, unstable angina, myocardial early period), diseases of the peripheral circulation (including intermittent claudication, Raynaud’s syndrome), epilepsy Parkinson’s disease, depression, glaucoma; moderate renal insufficiency (creatinine clearance 30-60 ml / min, serum creatinine 105-160 mmol / l), liver failure; pregnancy.

Application of pregnancy and during breastfeeding

No significant trials of moxonidine in pregnant women have been conducted. Animal studies have shown embryotoxic effect. Clinical data on the negative impact on the course of pregnancy there. However, you should use the pregnancy only if the potential benefit to the mother outweighs the potential risk to the fetus.

Moxonidine passes into breast milk, women during treatment is recommended to stop breast-feeding or stop the drug.

Dosing and Administration

Moksoniteks appointed inside, regardless of meals, drinking plenty of fluids. the dose regime selected individually.

Unless otherwise Moksoniteks prescriptions should be administered in the following doses: as an initial dose of 0.2 mg of the drug administered in the morning. When insufficient therapeutic effect, the dose 3 weeks later increased to 0.4 mg / day in single or 2 divided doses. The maximum daily dose – 0.6 mg, the maximum single dose of 0.4 mg.

In patients with moderately severe renal function lesions (CC 30 – 60 ml / min), a single dose should not exceed 0.2 mg and the maximum daily dose – 0.4 mg.

Side effect

According to the World Health Organization (WHO) side effects are classified according to their rate of development as follows: common (> 1/100, <1/10), uncommon (> 1/1000, <1/100), rarely (> 1 / 10,000, <1/1000) and very rare (<1/10000), including isolated reports.

Cardio-vascular system
Uncommon: bradycardia, marked reduction in blood pressure (including orthostatic hypotension).

On the part of the central nervous system
often: dizziness (vertigo), headache, somnolence, insomnia
Uncommon: fainting, increased excitability.

On the part of the organ of hearing and labyrinth disorders
Uncommon: tinnitus.

From the digestive system
very often: dryness of the oral mucosa;
frequently: diarrhea, nausea, vomiting, dyspepsia.

Skin and subcutaneous tissue disorders
common: pruritus, rash,
rare: angioneurotic edema (angioedema).

On the part of the musculoskeletal and connective tissue disorders
common: pain testosterone propionate buy in the back,
rare: pain in the neck.

General disorders and administration site in
common: asthenia;
rare: peripheral edema.

Overdose

Symptoms: headache, marked reduction of blood pressure, bradycardia, palpitations, weakness, drowsiness, dryness of the oral mucosa, rarely – vomiting, and epigastric pain. Potentially possible paradoxical hypertension and hyperglycemia.

Treatment: symptomatic. No specific antidote.

In marked decrease in blood pressure it is recommended to restore the circulating blood volume due to fluid administration.

Alpha-adrenoceptor antagonists can reduce or eliminate transient hypertension moxonidine in overdose.

Interaction with other drugs

The combined use of Moxonidine with other antihypertensives leads to additive effect. Tricyclic antidepressants may decrease the effectiveness of antihypertensive drugs central action, and therefore it is not recommended taking them together with moxonidine.

Moxonidine may enhance the sedative effect of tricyclic antidepressants, tranquilizers, ethanol, sedatives and hypnotics.

Moxonidine is able to moderately improve cognitive impairment in patients receiving lorazepam.

Moxonidine may enhance the sedative effects of benzodiazepines in their simultaneous application.

Moxonidine is obtained by tubular secretion, so it is possible its interaction with other drugs that are excreted by tubular secretion.

special instructions

During treatment requires regular monitoring of blood pressure, heart rate and ECG. If necessary, cancel both received beta-blockers and drug Moksoniteks first cancel beta-blockers, and only after a few days of preparation Moksoniteks.

There is currently no evidence that discontinuation of Moksoniteks drug leads to increased blood pressure. But we should not abruptly stop the drug use Moksoniteks. Elderly patients may be at increased risk of cardiovascular complications due to the use of antihypertensive drugs, so drug therapy Moksoniteks should start with the lowest dose.

Effects on ability to drive vehicles and mechanisms

Effect of the drug Moksoniteks on ability to drive vehicles or operate machinery has not been studied. However, taking into account the possibility of dizziness, drowsiness, patients should be careful during the occupation of potentially hazardous activities that require attention, such as driving a vehicle or management technique, which requires high concentration testosterone propionate buy of attention. Anastrozole side effects, anastrozole 1 mg bodybuilding anastrozole for men.